Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain
نویسندگان
چکیده
منابع مشابه
Weight gain in Asian patients on second-generation antipsychotics.
INTRODUCTION There is increasing evidence that second-generation antipsychotics are associated with weight gain. However almost all available literature has been for Caucasian populations. MATERIALS AND METHODS A health quality improvement project was undertaken at the Institute of Mental Health/Woodbridge Hospital to monitor patients who were started on second-generation antipsychotics. This...
متن کاملInteractions between antiepileptics and second-generation antipsychotics.
INTRODUCTION Pharmacokinetic and pharmacodynamic drug interactions (DIs) can occur between antiepileptics (AEDs) and second-generation antipsychotics (SGAPs). Some AED and SGAP pharmacodynamic mechanisms are poorly understood. AED-SGAP combinations are used for treating comorbid illnesses or increasing efficacy, particularly in bipolar disorder. AREAS COVERED This article provides a comprehen...
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Antipsychotic-induced extrapyramidal adverse effects are well recognized in the context of first-generation antipsychotic drugs. However, the introduction of second-generation antipsychotics, with atypical mechanism of action, especially lower dopamine receptors affinity, was met with great expectations among clinicians regarding their potentially lower propensity to cause extrapyramidal syndro...
متن کاملDopamine, Striatum, Antipsychotics, and Questions About Weight Gain.
For decades, psychiatrists worried about the adverse motor effects of antipsychotics and tried tounderstandwhat caused them and why some patients developed them and others did not. In the late 1990s, the game changed. The new atypical antipsychotics caused fewer adverse motor effects but causedmoreweight gain. At present, a large number of patients with schizophrenia experience a clinically imp...
متن کاملDisturbances of glucose and lipid metabolism during treatment with new generation antipsychotics.
PURPOSE OF REVIEW The purpose of this paper is to review the recent literature about alterations of lipid and glucose metabolism in patients treated with second generation antipsychotics. This article also addresses possible underlying mechanisms of these changes and discusses ways of preventing these side-effects as well as their management. RECENT FINDINGS There is a considerable number of ...
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ژورنال
عنوان ژورنال: Cells
سال: 2019
ISSN: 2073-4409
DOI: 10.3390/cells8111336